| abstract |
The invention relates to a transdermal therapeutic system in the form of a patch for controlled release of estradiol in combination with noresthisteron acetate, comprising a backing layer, a reservoir attached thereto and oversaturated with active substances, which is produced using polyacrylate contact-sensitive adhesives and crystallization inhibitors, in addition to a removable protective layer. The inventive system is characterized in that the crystallization inhibitor is a terpolymer based on butyl methacrylate, 2-dimethylamino ethylmethacrylate and methylmethacrylate, especially in a molar ratio of 1 : 2 : 1. |