| abstract |
An MMP-proenzyme activator (MMP-PA) that is expressed by articular cartilage. An MP-PA, biologically active fragments and mutants thereof, the cleavage products generated by the enzyme, and compounds (e.g., antibodies or small molecules) that modulate the MMP-PA's activity can be used to diagnose, monitor, and treat conditions in which articular cartilage is either lost or overproduced. |