| abstract |
The invention discloses use of a compound of the benzofuroxan series for treatment of cardiovascular disorders represented by general formula (I) and pharmaceutically acceptable salts thereof, wherein R is halogen, acetoxy, -X-R', -C(O)NR''R''', or -C(O)CI, wherein X is oxygen sulfur, -C(O)-, or -C(O)O-; R' is hydrogen, straight chain or branched lower alkyl (C1-C8); R'' and R''' is independently hydrogen, straight chain or branched lower alkyl (C1-C8) or R'' and R''' are linked together with or without heteroatom such as oxygen or nitrogen wherein substitution on nitrogen is hydrogen or lower alkyl. The invention further discloses pharmaceutical compositions containing compounds of general formula (I) as active ingredients. The invention also discloses a method of treatment of mammal, including man, of coronary heart disease by administration of an effective amount of a compound of formula (I) as defined above. |