| abstract |
Compounds having sPLA2 inhibitory effect represented by general formula (I), prodrugs thereof, pharmaceutically acceptable salts thereof or solvates of the same, and sPLA2 inhibitors containing the same as the active ingredient, wherein R1 represents -(L1)-R6 (wherein L1 represents a divalent linking group having 1 to 18 atoms, etc.; and R6 represents a carbon ring having one or more non-interfering substituents, etc.); R2 represents C¿1-3? alkyl, etc.; R?3¿ represents -(L2)-(acidic group); R?4 and R5¿ represent each hydrogen, a non-interfering substituent, a carbon ring, etc.; Xs independently represent each oxygen or sulfur; and RA represents -C(=X)-C(=X)-NH¿2?, etc. |