| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c4322cb4de342be2dbedcbe0c278f6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_612a97eef4d939507b857fcc060d243c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6c0ae83cc284dde720e4e5754d8a24c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-646 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
1999-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e2c8c546509fae6b432fc53f4fefef6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c411a989d76b06c9b0d227cfbc28ae65 |
| publicationDate |
1999-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9950303-A2 |
| titleOfInvention |
Immune response modulator alpha-2 macroglobulin complex |
| abstract |
Activation of α2-macroglobulin (α2M) with a nucleophilic compound followed by incubation of the activated α2M at elevated temperature with a biomolecule results in covalent incorporation of the intact biomolecule into the α2M molecule, without the use of proteinases. The thus-formed structurally defined and stable complex may be used as an antigen for stimulating the immune response, for example, in the form of a vaccine. Enhanced antigen presentation of a particular biomolecule is provided, especially for those that are poorly immunogenic; reduction of the immunodominance of particular epitopes is also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8029808-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7186515-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7179462-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9248172-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6984389-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7449557-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7666581-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9352019-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8591890-B2 |
| priorityDate |
1998-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |