| abstract |
The invention concerns anti-tumour agents of formula (I), wherein each of R?1, R2 and R3¿ has the meanings defined in the specification including hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl and (1-4C)alkoxy; each of R?4 and R5¿ is (1-4C)alkyl; each of R?6 and R7¿ is hydrogen or (1-4C)alkyl; X is N-(1-4C)alkylimino, N-(3-4C)alkenylimino or N-(3-4C)alkynylimino; m is 1 or 2 and each R8 is as defined in the specification; each of Y?1 and Y2¿ is halogeno, (1-4C)alkanesulphonyloxy, benzenesulphonyloxy or phenyl-(1-4C)alkanesulphonyloxy; or a pharmaceutically acceptable salt thereof; provided that at least one of R?1, R2 and R3¿ is other than hydrogen; a process for their preparation, pharmaceutical compositions containing them and their use in the production of an anti-proliferative effect. |