| abstract |
1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines of formula (I) in which Y is oxygen or H2, one of R?1 and R2¿ is halo, alkyl, alkoxy, alkylamino, dialkylamino, cyano, or carbamoyl, the other of R?1 and R2¿ is independently hydrogen, halo, alkyl, alkoxy, alkylamino, dialkylamino, cyano, or carbamoyl and; R3 is hydrogen, alkyl, or benzyl, and the method of reducing levels of tumor necrosis factor α and other inflammatory cytokines in a mammal through the administration of such derivatives, and pharmaceutical compositions containing such derivatives. |