| abstract |
The analgesic effectiveness of a narcotic agonist-antagonist analgesic is significantly potentiated by administering a narcotic agonist-antagonist analgesic together with at least one nontoxic NMDA receptor antagonist. The narcotic agonist-antagonist analgesic is selected from the group consisting of pentazocine, nalbuphine, butorphanol, buprenorphine, meptazinol, dezocine, nalorphine, cyclazocine and pharmaceutically acceptable salts thereof. The nontoxic NMDA receptor antagonist is at least one member selected from the group consisting of dextromethorphan, dextrophan, amantadine, memantine and pharmaceutically acceptable salts thereof. |