| abstract |
Methods and compositions for inhibiting rejection of an implanted device in an implant recipient, particularly of an implanted immunoisolation device, are disclosed. The present methods and compositions are suitable for use with devices comprising cells or tissue, such as endocrine or neuroendocrine tissue, or hepatic tissue, to deliver a variety of secreted products or enzymatic processes to the implant recipient. Rejection is inhibited through use of a CD40:CD154 binding interruptor, such as a CD154 blocking agent, preferably a monoclonal antibody which binds specifically to CD154 and prevents its interaction with CD40. |