http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9945922-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D339-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D339-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-00 |
| filingDate | 1999-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a763de7fbc6bbfd3f9ec11afb7939f8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0767e09c2371bb2f646ab92dbf64d8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c78a1c418c4e8d984ec3af959796d4a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da38ee30476169cdf7840d5313bca460 |
| publicationDate | 1999-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9945922-A1 |
| titleOfInvention | Lipoic acid analogs |
| abstract | A compound is provided having formula (I) wherein R?1 and R2¿ independently denote a methylene, ethylene or unbranched or branched C¿3-16? alkylene, alkenylene or alkynylene group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in the unbranched or branched C3-16 alkylene, alkenylene or alkynylene group an internal alkylene carbon atom in the carbon backbone thereof can be replaced by an oxygen atom, R?3 and R4¿ (i) independently denote (a) hydrogen, (b) a methyl, ethyl, vinyl or unbranched or branched C¿3-16? alkyl, alkenyl or alkynyl group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in said unbranched or branched C3-16 alkyl, alkenyl or alkynyl group an internal alkylene carbon atom in the carbon backbone thereof can be replaced by an oxygen atom, (c) a cycloalkyl, alkylcycloalkyl, alkynylcycloalkyl or alkynylcycloalkyl group having 5 to 16 carbon atoms which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, or (d) an aryl, alkaryl, aralkyl, alkenylaryl, aralkenyl, alkynylaryl or aralkynyl group having 6 to 16 carbon atoms which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, or (ii) jointly with the nitrogen atom form a cyclic or aromatic amine which is unsubstituted or substituted with one or more alkyl, alkenyl, alkynyl, halogen, hydroxyl or amine groups, X denotes O, S, -NH- or -NR?5¿-, and R5 denotes methyl, ethyl, or unbranched or branched C¿3-16? alkyl, or a pharmaceutically acceptable salt thereof, wherein t he compound is in equilibrium at physiological pH with a protonated form thereof. Methods of making the compounds, compositions including the compounds and methods of treatment of conditions involving reactive oxygen species are also provided. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8772249-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8772250-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8815937-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10111048-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6607735-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7928067-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9540417-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2060189-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9289503-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11213509-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9359325-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10744115-B2 |
| priorityDate | 1998-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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