| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7449ca99fbf1c556219fe28876cbf2a9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate |
1999-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40c4c73b507632b678fc04659b8bc62f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9740cf731d518b37fa8377c2cf93d522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6f8797c02daba9995d9f0c033f69285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32df4ed3b6116de12a69078d247e2311
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c18875d2506aaf55b42e4409b8926e5d |
| publicationDate |
1999-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9945113-A1 |
| titleOfInvention |
Smad binding elements and uses thereof |
| abstract |
The invention provides isolated nucleic acids including one or more Smad binding elements (SBEs) and Smad proteins and fragments thereof which bind to Smad binding elements. The invention also provides TGFβ response elements which confer TGFβ superfamily responsiveness to genes which have such elements in transcriptional control regions. Also provided are methods for using the Smad binding elements in methods of screening for compounds which bind the Smad binding element and in methods for modulating the binding of Smad proteins to Smad binding elements, e.g. to modulate TGFβ signal transduction. Further, the identification of a mammalian Smad binding sequence permits identification of the SBE binding determinants of Smad proteins. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006019954-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006019954-A3 |
| priorityDate |
1998-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |