| abstract |
The present invention is directed to methods and compositions for preventing β-cell destruction and for ameliorating obesity related NIDDM. More particularly the present inventors have found that β-cell destruction occurs in obesity related NIDDM through the action of ceramides. The present invention suggests that ceramides mediate their cytotoxic influence through increased NO production. More particularly, the active agents for preventing β-cell destruction in obesity related NIDDM are troglitazone, leptin, triacsin and fumosinins, and no-production inhibitors, like aminoguanidines. |