| abstract |
Novel sulphonamide derivatives of formula (I) or a salt thereof having CNS activity, processes for their preparation and their use as medicaments: in which E is -SO2NH- or -NHSO2- P is a phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur; A is a single bond, a C1-6alkylene or a C1-6alkenylene group; R1 is halogen, C¿1-6?alkyl optionally substituted by one or more fluorine atoms, C3-6cycloalkyl, C1-6alkoxy, OCF3, C1-6alkoxyC1-6alkoxy; C1-6alkanoyl, amino, alkylamino or dialkylamino, SR?11¿ where R11 is hydrogen or C¿1-6?alkyl or R?1¿ is phenyl, benzyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur; and n is 0, 1, 2, 3, 4 or 5; R3 is a group R5 or together with R5 forms a group (CH¿2?)2O or (CH2)3O; R?4¿ is selected from a group of formula (i), (ii) or (iii): Formula (i) in which R6 is C¿1-6?alkyl optionally substituted by one or more halogen atoms; m is 0, 1 or 2; q is 0, 1, 2, 3 or 4; or Formula (ii) in which R?6¿, m and q are as defined in formula (i); or Formula (iii) in which R6, and q are as defined in formula (I) and R7 is hydrogen or C¿1-6?alkyl; R?5¿ is hydrogen, halogen, C¿1-6?alkoxy optionally substituted with one or more fluorine atoms, trifluoromethyl, or together with R?3¿ forms a group (CH¿2?)2O or (CH2)3O. |