| abstract |
A novel acetamide derivative represented by formula (1), which has inhibition activity for a chymotrypsin type protease and is useful as an inhibitor for the above enzyme, especially as an inhibitor for chimase, and the use thereof as a medicine, for example, an antiasthma drug or a drug for angiolasty or for caring the injury of a blood vessel complexed with atheroma. In chemical formula (1) R0 represents a substituted or non-substituted phenyl group, R1 represents an aryl, a heteroaryl or an aliphatic lower alkyl group with or without a substituent, R2 represents a substituted or non-substituted alkyl, arylalkyl, heteroarylalkyl or heteroaryloxyalkyl group or the like, J represents a carbonyl or methylene group or the like, L represents a methoxy, hydroxy or acetyloxy group or the like, X and Y independently represent a nitrogen atom or a carbon atom and Z represents a methylene group or a polyethylene group optionally having a substituent. |