| abstract |
The present invention relates to a compound of formula (1) wherein A is of formula (2), (3), (4), B is phenyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, thienyl, thiazolyl, furyl or oxazolyl, the ring being substituted on ring carbon atoms by R1 and -(CH¿2)nR?2; or B is pyrrolyl, pyrazolyl or imidazolyl, and when A is of formula (2) or (3), B can also be naphthyl substituted by R1 and -(CH¿2?)nR?2; R1¿ is of the formula -CONHCH(R10)R11 wherein R11 is of the formula -CH¿2?OR?13, -COR14¿ or -CH¿2?COR?14 or R11¿ is morpholinoC¿1-4?alkyl, pyrrolidin-1-ylC1-4alkyl or piperidin-1-ylC1-4alkyl; or R?11¿ is phenyl-1-hydroxyC¿1-4?alkyl; or heteroaryl-1-hydroxyC1-4alkyl; R?2¿ is phenyl or heteroaryl; and n is 0, 1 or 2; or a prodrug, solvate or pharmaceutically-acceptable salt thereof. Processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them. A particular use is in cancer therapy. |