| abstract |
There is provided modified methods and apparatus for the preparation of arrays of material wherein each array includes a preselected collection of polymers, small molecules or inorganic materials associated with a surface of substrate. The methods provide for modifications to general apparatus, flow cell geometries and solutions used in array fabrication. In one embodiment a method of removing static charge during the fabrication of an array is described. The method of static charge removal may include, but is not limited to, use of an ionizing fan or ion bars. In particular, equipment for removing static charges is placed at each entry and exit point in the flow cell. In another embodiment optimized flow cell geometries are provided. In another embodiment the introduction of phosphoramidite during array fabrication is provided. In another embodiment a deprotection solution comprising alkylamine is provided. |