| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97c9b2944292747b34d1f68efa43a730
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22dd8be373b0ff7115dcee7d5978fae4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e76c6ae6fc2d62ee24c8b188d4c5f3a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0676
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-507
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
1999-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66e59db2dc7b1a46f9b29afa39a298c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95b1d175ee8683be8994d0f1ae8982b6 |
| publicationDate |
1999-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9935255-A2 |
| titleOfInvention |
Compositions and methods for regulated secretion from neuroendocrine cell lines |
| abstract |
The present invention provides compositions and methods of comprising engineered human neuroendocrine cell lines having a regulated secretory pathway. More particularly, the present invention provdes methods and compositions for engineering regulated secretion into cells. Certain aspects of the invention provide glycemic sensing mechanisms to a population of genetically engineered cells. In particular embodiments, the present invention provides compositions and methods of providing indirect glycemic sensing mechanisms to a population of genetically engineered cells. Specifically contemplated are methods and compositions for engineering indirect glucose sensing and glucose counter regulation capacity into cells. Methods of using these cells for minimizing hypoglycemia in diabetic therapy are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11312936-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I797060-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10531655-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8431533-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10271539-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8945876-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8790705-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8853159-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11332771-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015077523-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10918110-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009033748-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2495307-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10927342-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009033748-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7166463-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011236431-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7341836-B2 |
| priorityDate |
1998-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |