http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9932621-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate | 1998-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7fde116af146c3a3042177ecd676cae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a6e8d65aefec4ae03de55b734fb4d75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c647fb448d9836a59c5b4662646e2cb |
| publicationDate | 1999-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9932621-A2 |
| titleOfInvention | Nucleic acid sequences encoding nuclear receptor coactivator proteins and uses thereof |
| abstract | A novel steroid receptor coactivator-3 (SRC-3), a coactivator of steroid nuclear receptor transcription was cloned and characterized. SRC-3 represents a new member of a family of steroid receptor coactivators that includes TAF-1 and TIF-2. SRC-3 demonstrated selective nuclear receptor-stimulated gene transcription in a ligand-dependent manner. Protein-protein interaction assays, including BIACORE analyses, demonstrated that the interaction between SRC-3 and ER a was much stronger than that observed for SRC-3 and ER b. An intrinsic transactivation function was observed in the C-terminal half of SRC-3. SRC-3 was differentially expressed in various tissues and, among several tumor cells examined, was most abundant in the nuclear fraction of MCF-7 breast cancer cells. Therefore, SRC-3 is a third member of a family of steroid receptor coactivators that has a distinct tissue distribution and intriguing selectivity between ER a and ER b. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11633428-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11633429-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11497772-B2 |
| priorityDate | 1997-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 418.