| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dda140480fcd3018216d19afee8b7fd8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e3c787ecff44cb6ae3d34eaf6d090f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c537e43b6c15a8b82bd26c0670e3165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23a4e0c875bf1ac2b8a3b76517de6c7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3a45afd9bcc397fc5a1edda9bee5e65 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D315-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D315-00 |
| filingDate |
1998-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd39ce2ed3aa51e9d18a7b61dcb120d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4ebd45df15f68c6c9afa1708140a628
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c65df0b25ecb92b398ae43fd0e7bc07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0763053672ee4cde5e4bff4695709b22 |
| publicationDate |
1999-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9931084-A8 |
| titleOfInvention |
Brefeldin a derivatives |
| abstract |
Cytotoxic Michael addition derivatives of brefeldin A are described. Oxidation of thiol addition products of brefeldin A provides the corresponding sulfoxides and sulfones. The sulfoxides exhibited more cytotoxic activity than the corresponding sulfides and sulfones in a variety of human cancer cell lines. Pharmaceutical formulations of the disclosed cytotoxic derivatives are also described. |
| priorityDate |
1997-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |