| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aee32ee4d927c3464c11ae4c41d0b557
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f6e33603375c486b0ab3505830af9e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa12a18f79ae874e92d7db17b384f824
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42fbe020e176c4687b438fa686a940de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65a5f64d50dd544ccc0631525026afc3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C66-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-94 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C66-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18 |
| filingDate |
1998-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d21c3e4d4a9c3cbab6367f58992ab56b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7b1939567f12ce83c34095cf9526ff5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca350bac55787cc06d04f39d7d1c4c73 |
| publicationDate |
1999-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9929706-A3 |
| titleOfInvention |
DISALICYLATE ANALOG BASED SIALYL LEWISx MIMETICS |
| abstract |
The present invention discloses medicaments that are selectin-ligand structural mimetics that bind to certain selectins wherein the mimetics may lack the sialic acid and/or fucose of the natural selecting ligand, sialyl Lewisx (sLex), but have a structure capable of mimicking the structural features necessary for selectin recognition. In particular, the invention compounds mimic the key structural features of the oligosaccharides responsible for selectin-mediated cell adhesion. These features consist of the charge-distance-coordination relationship between the carboxylic acid functionality of sialic acid at a distance of 8-12 angstroms of the L-fucose moiety. The invention compounds are disalicylate, its analogs, and disalicylate-based C-glycoside compounds. The present invention also discloses methods of treating selectin-mediated disorders comprising administering the compounds disclosed. |
| priorityDate |
1997-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |