| abstract |
This invention provides a process for the preparation of a Eleutherobin derivative of formula wherein R1 is a hydrogen, ester, nitrile or CH2-R4 (I), wherein R4 is a carbohydrate, an alcohol, an amine, an amide, an alkyne; or R2 is a linear or branched alkyl moiety; R3 is an ester, an amide, a carbamate, an acetal compound, an ether or a urethane; R4 is a hydrogen or CH2; position C2 and C3 is cis or trans; position C8 is α or β and a compound is produced having the structures (II) and (III). Additionally, this experiment provides a method for inhibiting growth of cancerous cells comprising contracting an amount of Eleutherobin derivative effective to inhibit the growth of said cells. Further provided is a method for treating cancer in a subject which comprises administering to the subject a therapeutically effective amount of the Eleutherobin derivative. |