| abstract |
A new method for the preparation of the anti-HIV antiviral compound 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (β-FddA) is provided. The method relies upon the stereospecific hydrogenation of 9-[2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl]adenine or various derivatives thereof. The methods are expected to be suitable for the preparation of other antiviral 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)purines, such as β-FddG and β-FddI. |