| abstract |
Compounds of formula (I) or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein the broken line represents an optional bond; A is C or CH; B is CH2, O or absent; R ?1 and R2¿ are each independently selected from hydrogen, C¿1? to C6 alkyl optionally substituted with C1 to C4 alkoxy or phenyl, and C1 to C6 alkenyl; or, together with the carbon atom to which they are attached, form a C3 to C6 cycloalkyl group which optionally incorporates a heteroatom linkage selected from O, SO, SO2 and NR?6¿ or which is optionally benzo-fused; R3 is hydrogen, halo, R?7 or OR7; R4¿ is hydrogen, C¿1? to C4 alkyl, C1 to C4 alkoxy, trifluoromethyl or halo; R?6¿ is hydrogen or C¿1? to C4 alkyl; R?7¿ is an optionally substituted monocyclic or bicyclic ring system; m is 1 or 2; and n is 0, 1 or 2; with the proviso that B is not O when A is C; are MMP inhibitors useful in the treatment of, inter alia, tissue ulceration, wound repair and skin diseases. |