Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47c7987af2508cd54bba59c6d47038c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0032dc8837535fda8a149a5d72103558 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-003 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-635 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
filingDate |
1998-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a03a8c4aac4311f13d771ae5481c1924 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76b4c06bd4da92791b0606a3b7a05358 |
publicationDate |
1999-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-9925856-A1 |
titleOfInvention |
System and method for regulation of gene expression |
abstract |
A control system for genetic expression includes a first, reporter polynucleotide molecule including a reporter sequence encoding a protein to be expressed operably linked to a heptameric tet operator sequence and at least two promoters and a second, regulator polynucleotide molecule including a sequence coding for a tet repressor protein and the KRAB protein. The reporter polynucleotide includes one promoter on each side of the tet operator sequence. In one embodiment a TK promoter is located upstream of the operator sequence and a CMV promoter is located downstream thereof. The desired nucleic acid sequence of the reporter molecule is positioned downstream of the CMV promoter. A method to regulate the expression of a protein using the system of the invention is provided. The invention also provides a kit including both the polynucleotides described above. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008050774-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2239326-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0052179-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0052179-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02074996-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2008050774-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010115583-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012029074-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014194130-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7189506-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8653046-B2 |
priorityDate |
1997-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |