| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4139569b1e404517cde5a95f0cce427d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed28726de9f916f355f8adc331e736b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16151 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 |
| filingDate |
1998-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19fc1172f1581fca8e7d516e50562911
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97fbfc202e078baddd64797da3751c44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_980d441d63a92d38ab24abe38ef1d236
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b03be2b9a345b18578009c9c2c0c340 |
| publicationDate |
1999-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9923203-A1 |
| titleOfInvention |
Immortalized, homozygous stat1-deficient mammalian cell lines and their uses |
| abstract |
The present invention is directed to immortalized STAT1-deficient mammalian cell lines. STAT1 is a signal transducer and activator of transcription that becomes phosphorylated when cells are treated with type I or type II interferons and leads to induction of specific gene expression, resulting in establishment of the antiviral state and the other known biological responses to interferons, including the inhibition of cell proliferation. Cells which lack this gene product are useful for producing high titers of viral stocks, for producing recombinant viral vectors, for testing samples, especially clinical samples for the presence of virus and for screening candidate compounds or drugs for anti-viral activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7183107-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1950313-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0212477-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0212477-A2 |
| priorityDate |
1997-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |