| abstract |
Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described. Wherein A = N, C; B = H, hydroxy, halogen, acyl (C1-C6), alkyl (C1-C6), alkoxy (C1-C6); D = O, S, NH2; E = H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, halogen, or any substituent which is readily cleaved in the body to generate any one of the before listed groups; and G = substituted or unsubstituted cyclic sugar, substituted or unsubstituted acyclic sugar, substituted or unsubstituted mono, di or triphospho-cyclic-sugar phosphate; substituted or unsubstituted mono, di, or tri-phosphoacyclic-sugar phosphate; substituted or unsubstituted mono, di or tri-phospho-cyclic sugar analogues, substituted or unsubstituted mono, di, or tri-phospho-acyclic sugar analogues wherein the substituants are alkyl (C1 to C6) alkoxy (C1 to C6), halogen. |