| abstract |
The invention relates to carboxylic acid derivatives of formula (I), wherein R6 represents a group (a) or (b), R?13 and R14¿ being the same or different and having the following meaning: hydrogen; on the condition that R?13 and R14¿ are not hydrogen at the same time, C¿1?-C8-alkyl, C3-C8-cycloalkyl, C3-C8-alkenyl, C3-C8-alkinyl, benzyl, phenyl, naphthyl, optionally substituted; or R?13 and R14¿ together form an optionally substituted C¿3?-C7-alkylene chain which is closed in a ring and in which an alkylene group can be replaced by oxygen, sulphur or nitrogen; or R?13 and R14¿ together form an optionally substituted C¿3?-7-alkylene chain or C3-C7-alkenylene chain which is closed in a ring and to which an optionally substituted phenyl ring is anellated. The other substituents have the meanings given in the description. The invention also relates to the production of the novel carboxylic acid derivatives and to their use as endothelin receptor antagonists. |