| abstract |
This invention relates to methods and compositions utilizing progastrin for the diagnosis and treatment of pathological conditions of the gastrointestinal tract, and in particular of conditions associated with proliferative or degenerative diseases of the gastrointestinal mucosa. In one embodiment the invention provides methods and compositions utilizing recombinant human progastrin6-80 for diagnosis and treatment of conditions associated with hyperprogastrinaemia, including colorectal carcinoma, duodenal ulcer, and gastrinoma, and side effects of treatment of gastric ulcer with ATPase blockers. In an alternative embodiment, the invention provides methods and compositions utilizing recombinant human progastrin6-80 for treatment of degenerative diseases of the gastrointestinal mucosa, such as ulcerative colitis and inflammatory bowel disease. |