http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9918085-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ef8acc27b4252e343aa5da877c870d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-04 |
| filingDate | 1998-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a047df6553f49dff999169b9947bdea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e035b324a71717e489a653586fb0f66b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50912e13ac3d13f8dcc342f2bbd3dee8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6a090f167c3eca809042b9e90ac728a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee1df7bb3ff36a7f154bea04857b5fee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b0a038bb0d6e1407e0c316c0939ad1c |
| publicationDate | 1999-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9918085-A2 |
| titleOfInvention | Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate |
| abstract | The present invention concerns an improved process for the preparation of asymmetric cyclic ureas as well as intermediates in the preparation of asymmetric cyclic ureas of formula (VI): wherein: R7 is selected from the following: C¿1?-C8 alkyl substituted with 0-3 R?11; C¿2-C8 alkenyl substituted with 0-3 R11; C2-C8 alkynyl substituted with 0-3 R11; and a C¿3?-C14 carbocyclic ring system substituted with 0-3 R?11; R10 is C1-C10¿ alkyl, benzyl, naphthylmethyl, 3,4-methylenedioxybenzyl, or C¿1?-C4 alkyl substituted with phenyl wherein said phenyl is substituted with 0-3 R?10a¿; G taken together along with the oxygen atoms to which G is attached forms a group selected from: -O-C(-CH¿2?CH2CH2CH2CH2-)-O-, -O-C(CH2CH3)2-O-, -O-C(CH3)(CH2CH3)-O-, -O-C(CH2CH2CH2CH3)2-O-, -O-C(CH3)(CH2CH(CH3)CH3)-O-, -O-CH(phenyl)-O-, OCH2O-, -OC(CH3)2O- and -OC(OCH3)(CH2CH2CH3)O-. In the process, a diamine of formula (I-a) is selectively monoacylated to give an asymmetric monoacylated diamine which can be converted into asymmetric intermediates. The asymmetric intermediates can be further alkylated, cyclized, and/or modified to give compounds which are useful as HIV protease inhibitors for the treatment of HIV infection. The invention allows for scalable preparation of a wide variety of asymmetrical cyclic ureas. |
| priorityDate | 1997-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 463.