| abstract |
Disclosed is a Ras-binding protein designated PRE1. PRE1 occurs naturally in various mammalian tissues and cell types. An isolated DNA endocing PRE1, vectors and cells containing the DNA, and PRE1-specific antibodies are also disclosed. Also disclosed is an in vitro screening method for indentifying a substance which modulates PRE1-Ras binding, and an in vitro method for identifying a substance that modulates PRE1 gene expression. |