| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c8cbbf2290b3f3a9988da29598baa2c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7720ddf3a9698d4b5c5b7b1bba47a328
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_035268bc2e22cf2cca1335e8599da74c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-59 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 |
| filingDate |
1998-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_490bab17cee595a764dfa7b5d06a59be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cb53d069815c5a3fe8de1e85cd2a423 |
| publicationDate |
1999-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9915665-A2 |
| titleOfInvention |
Mutants of thyroid stimulating hormone and methods based thereon |
| abstract |
The present invention is based upon the discovery that mutant α subunits and mutant β subunits each comprising amino acid substitutions relative to the wild type can be produced and assembled to form a mutant TSH heterodimer or TSH analog that possesses higher bioactivity in vitro and longer half life in vivo. Accordingly, the present invention provides methods for using mutant TSH heterodimers, TSH analogs, fragments, and derivatives thereof for treating or preventing diseases of the thyroid, in particular thyroid cancer. The invention also relates to methods of diagnosis, prognosis and monitoring for thyroid-related functions. Pharmaceutical and diagnostic compositions, methods of using mutant TSH heterodimers and TSH analogs with utility for treatment and prevention of metabolic and reproductive diseases are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005056046-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005056046-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009081170-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009081170-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009115809-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100423735-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009115809-A2 |
| priorityDate |
1997-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |