| abstract |
Process for recovery of a β-lactam antibiotic from a mixture containing β-lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between 3 and 8 at a temperature between -5 and 20 °C and at a concentration such that FG remains in solution, the solid β-lactam antibiotic obtained being recovered and the remaining liquid being subjected to a temperature increase to a temperature between 10 and 60 °C, with formation of solid FG, FG being separated out as a solid, and the mother liquor being at least partially recirculated. Use is preferably made of an initial mixture substantially containing β-lactam antibiotic and FG originating from an enzymatic acylation reaction in which the corresponding β-lactam nucleus, in particular 6-aminopenicillanic acid, 7-aminodesacetoxycephalosporanic acid and 7-amino-3-chloro-cef-3-em-4-carboxylic acid, is acylated with a D-phenyl glycine derivative. |