http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9914374-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1bf3e008c4ff31c5f042f50649af41b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_146b160f82e4be33cb0b5f9a8170b361 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 1998-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab53abb03f7c65541acc582cc636fb28 |
| publicationDate | 1999-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9914374-A2 |
| titleOfInvention | Methods for determining genetic susceptibility to diabetic nephropathy |
| abstract | The present invention provides novel method for detecting a genetic predisposition for diabetic nephropathy. In one aspect, the method comprises comparing a nucleic acid encoding for normal human angiotensin type II receptor (AT1) with that found in an individual to be tested. In other embodiments, the method comprises detecting a nucleic acid sequence within a span of about 20 centimorgans around the human ATI locus on chromosome 3q, which has been found to be genetically linked with the occurrence of diabetic nephropathy. In a further preferred embodiment, the method comprises comparing a nucleic acid encoding for normal human CD10/neutral endopeptidase 24.11 gene, with that found in an individual to be tested, wherein differences in sequence indicate a predisposition for diabetic nephropathy. In another aspect, the present invention also provides a novel method for detecting genetic linkage for diabetic nephropathy which comprises genetic analysis of nucleic acid from sibling-pairs who are concordant for type I diabetes, but are discordant for diabetic nephropathy pathology. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0075294-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101624630-B |
| priorityDate | 1997-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 222.