| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94ff2d78578d95d1e8d3a2233c76188d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 |
| filingDate |
1998-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f186cb79a6af018a6837d4f6b3694fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b00a3fcaa1869097b2bf81523e2a53a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd6c2630301f634a4febc8821e1858bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b37c275415bf2dd75f29f1fd20cd2e9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7757972dfa99c09d1987692068dfd109
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bc8acf5b2438cae071771a3acc0e2cf |
| publicationDate |
1999-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9912899-A1 |
| titleOfInvention |
A process for making prostaglandin f analogs |
| abstract |
Described is a process for making prostaglandin F analogs, the process comprising the steps of: I) preparing an intermediate having a structure according to Formula (A): wherein R?6 and R7¿ are as defined in the specification; wherein the preparation comprises: (a) reacting a Corey aldehyde with an activated alcohol to form an acetal derivative; (b) deprotecting the acetal derivative of step (a) to form a hydroxy acetal; (c) optionally reprotecting the hydroxy acetal of step (b); (d) reducing (b) or (c) to provide a lactol derivative; and (e) condensing the lactol derivative of step (d) with a phosphonium salt to form the intermediate ketal of Formula (A), or a salt or protected form thereof; II) removing the ketal form the intermediate of Formula (A) formed in step (I) to form an aldehyde and coupling the aldehyde with a Wadsworth-Horner-Emmons reagent or a Wittig-Horner reagent to form a product, and III) conducting one or more subsequent synthetic steps on the product of step (II) to form a prostaglandin F analog. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8906962-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9579270-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9006291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6586463-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE43372-E
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0051980-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9346837-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1267803-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7498458-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9675539-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8084501-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7268239-B2 |
| priorityDate |
1997-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |