| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e777007256cdb55a5134d12400966856
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afc21e2d4ebd88edf1c96e3ae8774ea1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ec46f41b6433509cc8a9750ffcf0afd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90f520b581fe388fb6c3136a0d677c9a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_98712bfdac294cd2a163023cc261714c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-2208
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 |
| filingDate |
1998-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5f775f5e6b3c4194dd33b9b6474bd0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f64b01bbc5896a0e8e566846e00d4879
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1489987dfe68d9b6843d610b66fdf2b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_156dc23385985f8b9cac33c68033869b |
| publicationDate |
1999-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9910292-A2 |
| titleOfInvention |
Robustaflavone, intermediates and analogues and method for preparation thereof |
| abstract |
Robustaflavone, intermediates and analogues thereof and a method for synthesizing the same are provided. The method involves constructing apigenin ethers containing functionalities at the 6- and 3'-positions which could be cross-coupled using transition metal catalysis. The method also involves development of a regioselective iodination of an apigein derivative at the 6-position, formation of an apigenin 3'-boronate using a palladium-catalyzed exchange of the corresponding 3'-iodide with a diboron reagent. Finally, Suzuki coupling to form the sterically congested 6-3''' biaryl bond of robustaflavone provides access to the desired biflavanoid system. Robustaflavone intermediates and analogues may be used to prepare analogues of other biflavanoids such as hinokifavone, rhusflavone and succedaneaflavone. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008086942-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008086942-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8119835-B2 |
| priorityDate |
1997-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |