| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05c50466850f4c42d21aabc1f994fae2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52a24331fe7882d8a0801155df05d542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f1be002e605f5334a88660da8757fa7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37baec45ee3bdf82463b00ae3ac17f8d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-00 |
| filingDate |
1998-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1b6291c76b05ce6dc3ec3fc64154914
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0863cb1216627ce1e53f3906b71cdb87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3118f29f008b4cc3d9eb345fc57ff558 |
| publicationDate |
1999-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9905277-A1 |
| titleOfInvention |
A recombinant expression vector of human parathyroid hormone using phosphoribulokinase as a fusion partner |
| abstract |
The present invention relates to a recombinant expression vector which is prepared by inserting a human parathyroid hormone gene containing a urokinase-specific cleavage site into an L-arabinose inducible vector containing a phosphoribulokinase gene fragment of Rhodobacter sphaeroides or its mutated gene as a fusion partner, a recombinant microorganism transformed with the said expression vector, and a process for preparing human parathyroid hormone on a large scale by cultivating the said microorganism in a medium containing L-arabinose. In accordance with the invention, a recombinant human PTH having the same activity of the native human PTH can be prepared in a high yield through the precise control of induction by a manufacturing process which comprises a step of inducing expression of fusion protein in the microorganism transformed with the recombinant expression vector by L-arabinose. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03008594-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8298789-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0148207-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10875913-B2 |
| priorityDate |
1997-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |