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publicationDate 1999-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9903451-A1
titleOfInvention Pharmaceutical formulations for oral administration
abstract Pharmaceutical formulations for oral administration which reduce the local gastrointestinal irritating effects of an active ingredient known to exibit such effects comprise the active ingredient, for example, a non-steroidal anti-inflammatory drug, dispersed in a milk protein, such as casein or the sodium salt thereof. These formulations are designed to exhibit a cytoprotective effect in the gastrointestinal tract. Controlled release of active ingredient can be achieved with the pharmaceutical formulations if the active ingredient and the milk protein are dispersed in a cellulose ether. The controlled release pharmaceutical formulations exhibit a substantially linear or positively curved release profile.
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