| abstract |
Novel naphthyridine compounds represented by general formula (1), having antagonistic effects on tachykinin receptors, and being useful as preventives or remedies for diseases in which tachykinin receptors seemingly participate: wherein R?1, R2 and R3¿ independently represent each hydrogen, lower alkyl, etc., or R?1 and R2 or R2 and R3¿ may be bonded to each other to form a cyclic group; X and Y represent each methylene or ethylene; Z represents optionally substituted phenyl, etc.; A represents hydrogen, lower alkyl, etc.; and G represents acyl. A particular example of the above compounds is 2-[(-)-4- (N-benzoyl-N-methyl) amino-3-(3,4-dichlorophenyl) butyl]-10-acetylamino-1,2, 3,4-tetrahydro-benzo[b] [1,6]-naphthyridine. |