| abstract |
This invention concerns compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein X is CH or N; R1 is hydrogen, C¿1-6?alkyl, C1-6alkyloxy, C1-6alkylthio, amino, mono- or di(C1-6alkyl)amino, Ar?1, Ar1¿NH-, C¿3-6?cycloalkyl, hydroxymethyl or benzyloxymethyl; R?2¿ is hydrogen, C¿1-6?alkyl, amino, aminocarbonyl, mono- or di(C1-6alkyl)amino, C1-6alkyloxycarbonyl, C1-6alkylcarbonylamino, hydroxy or C1-6alkyloxy; R?3, R4 and R5¿ are each independently selected from hydrogen, halo, C¿1-6?alkyl, C1-6alkyloxy, trifluoromethyl, nitro, amino, cyano, azido, C1-6alkyloxyC1-6alkyl, C1-6alkylthio, C1-6alkyloxycarbonyl or Het?1¿; formula (1) is Ar?2, Ar2CH¿2- or Het?2; Ar1 and Ar2¿ optionally substituted phenyl; Het1 and Het2 are optionally substituted monocyclic heterocycles; having angiogenesis inhibiting activity; their preparation, compositions containing them and their use as a medicine. |