| abstract |
3-aminoindanones of formula (I) are described for pharmaceutical use, especially as anti-inflammatory agents and/or mast cell stabilising agents. In formula (I) R1 to R9 are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, aryl, acyl, alkyl carbonyl, aryl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrozone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing hetero atoms selected from one or more of N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms, substituted alkyl, carboxylic acid containing C¿1? to C10 which may be substituted or unsubstituted; any of: R?1 and R2; or R2 and R3¿ together may represent a double bond; R?1 or R2 or R1 and R2¿ together may represent oxo. |