| abstract |
2,3-Dihydrobenzofuran derivatives represented by general formula (1), optically active isomers thereof, or pharmacologically acceptable salts of these, wherein R1 represents hydrogen or acyl; R2, R3, and R4 each represents hydrogen, lower alkyl, or lower alkenyl; and R5 and R6 each represents hydrogen or optionally substituted alkyl, or R5 and R6 in combination represent cycloalkyl or a saturated heterocycle containing one or more oxygen atoms or alkyl-substituted nitrogen; provided that not both of R2 and R3 are t-butyl. The compounds are useful as remedial or preventive agents for various kidney diseases and as organ preservatives. |