http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9849555-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fc2a22a9271507062ad7e07974d3c58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 |
| filingDate | 1998-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c7890ea55e3fd40a63b8c3207d0b0a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94ee50d45821046f7659d452109f1ba8 |
| publicationDate | 1998-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9849555-A1 |
| titleOfInvention | Methods for identifying ligands for nuclear hormone receptors |
| abstract | Fatty acids (FAs) and their derivatives are essential cellular metabolites whose concentations must be closely regulated. This implies that regulatory circuits exist which can sense changes in FA levels. Indeed, the peroxisome proliferator activated receptor α (PPARα) regulates lipid homeostasis and is transcriptionally activated by a variety of lipid-like compounds. It remains unclear as to how these structurally-diverse compounds can activate a single receptor. In accordance with the present invention, there are provided conformation-based assays which screen activators for their ability to bind to PPARs (i.e., PPARα, PPARδ and PPARη) and induce DNA binding. It is shown here that specific FAs, eicosanoids and lipomodulatory agents are ligands for PPARα, PPARδ and/or PPARη. Since altered FA levels are associated with obesity, atherosclerosis, hypertension and diabetes, PPARs may serve as molecular sensors which are central to the development and treatment of these metabolic disorders. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004509895-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0224702-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1386610-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012030165-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2843026-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6518041-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19855013-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19855013-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100765670-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6184256-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1307181-C |
| priorityDate | 1997-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 145.