http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9849179-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc16e74a7425cd30980d3d9ae0b62a30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_509187decb9ec075f7d490b92060cb10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9245f44fe631908089d30e01ce5ff06f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_019297bfc9c10aa1669678d3b5e92e51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e71b4fabc406447250d13660458b3252 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate | 1998-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da0ae1760d071e605a0a13ab50bf478d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06a539c249e4ca3e20e8117c3ef64a9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bf118d09ef46f28b7bfec6716153913 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39c28c2167dc6b614bc24fa9ae34b1ea |
| publicationDate | 1998-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9849179-A2 |
| titleOfInvention | A process for the synthesis of modified p-chiral nucleotide analogues |
| abstract | The process for the synthesis of modified P-chiral nucleotide analogues of general formula (1) in the form of pure diastereomer possessing preselected configuration at the P-atom, where: R1 stands for a protecting group, preferably 4,4'-dimethoxytrityl (DMT), 9-phenylxanthene-9-ol (Px) or trialkylsilyl group; R2 is a hydrogen atom, protected hydroxyl group, halogen, chloroalkyl, nitrile, azide, protected amine group, perfluoroalkyl (containing up to four carbon atoms), perfluoroalkoxyl (containing up to four carbon atoms and up to nine fluorine or chlorine atoms), alkoxyalkyl, vinyl, ethynyl, OQ1, SQ1, NHQ1, where Q1 stands for alkyl (C1-C4), aryl (C6-C12), alkenyl (C3-C12) or alkynyl (C3-C12); B stands for a purine or pyrimidine base (appropriately protected at nitrogen atoms if necessary); Z is selected from Q1 or vinyl, ethynyl, aminomethyl or aminoethyl substituents; X means an oxygen, sulfur or selenium atom; Rx is a protecting group, preferably aroyl, acyl, alkoxycarbonyl, benzenesulfonic, alkyl, trialkylsilyl group or the next unit of elongated oligonucleotide chain. Antisense oligonucleotides containing P-chiral compounds of general formula (1) have enhanced hybridization and transporting properties. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7982030-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7592446-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02077002-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02077002-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8354524-B2 |
| priorityDate | 1997-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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