| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2427716fc69ab2e2d3493d8d6385c6aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ccb63c5435a44030c16ca7fb977d032
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_653bf3b10d6b83cdb4bddfd580ff92c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ee4e733ff3aa71c300ffc00483332df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e99fe3dfb69887d76b7ff5ae08d0c810
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fadf500555621178391436688d7e032 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-02 |
| filingDate |
1998-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93a6a8932eb31827328db4ce55ee4b0d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3e0a00537c9f50992b0ba23ad726f6e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0482d24ff03ecbb536cd99710887f3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78582b1965bdbe00d91e9d6e7bfbd9b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19ea78a0005c64c7f86c27d4643d2926 |
| publicationDate |
1998-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9848036-A1 |
| titleOfInvention |
Improved process for the fermentative production of cephalosporin |
| abstract |
The present invention relates to a novel process for the preparation of cephalosporins having been deacylated at the 7-amino group, by fermentation of a cephalosporin producing microorganism in the presence of a side chain precursor, extraction of the N-substituted cephalosporin compound as present in the fermentation broth or fluid to an organic solvent, back extraction of the N-substituted cephalosporin compound to water, treatment of the aqueous phase with a dicarboxylate acylase and isolation of the crystalline cephalosporin compound according to formula (1) from the conversion solution, characterized in that the fermentation broth or fluid is incubated at acidic conditions and an elevated temperature prior to extraction of the N-substituted cephalosporin compound to an organic solvent. Further improvements of the process are obtained by washing the first organic solvent extract with acidified water and/or by extraction of the side chain to an organic solvent and/or by treating an aqueous cephalosporin solution produced at one or more stages in the process of the invention with carbon dioxide. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012117038-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003533529-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-023822-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012032040-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7767823-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9950271-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103429596-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103429596-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6803460-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6552185-B1 |
| priorityDate |
1997-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |