abstract |
The present invention relates to phosphonic acid derivatives of formula (I), or a pharmaceutically acceptable salt or hydrate thereof, wherein Y is selected from the group consisting of CR1R2, NR3 and O; and X and R are selected from hydrogen or (substituted) hydrocarbyl groups; that inhibit N-Acetylated α-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and method of using such derivatives to inhibit NAALADase actitivty, to treat a glutamate abnormality and to treat a prostate disease in an animal. |