| abstract |
Compounds of formula (I), processes for their preparation and their use as CNS agents are described, in which Ra is a group of formula (i) in which P1 is bicyclic aryl, or a bicyclic heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur; or Ra is a group of formula (ii) wherein P?2 and P3¿ are independently phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a bicyclic heterocyclic group containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur, providing that at least one of P?2 and P3¿ is a bicyclic aryl or bicyclic heterocyclic group; L is a group of formula -C(=V)-DG- or -DG-C(=V)- or -Y-C(=V)-DG1-; V is oxygen or sulphur; D is nitrogen, carbon or a CH group; G and G1 are each hydrogen or C¿1-6?alkyl; Y is -NH- or -NR?5¿- where R5 is C¿1-6?alkyl, or Y is -CH2- or -O-; X is nitrogen or carbon; R?b1 and Rb2¿ are independently hydrogen, halogen, hydroxy, C¿1-6?alkyl, trifluoromethyl, C1-6alkoxy or aryl, or R?b1¿ together with G forms a group W as defined above; Rc is hydrogen or C¿1-6?alkyl. |