| abstract |
Compounds of formula (I), in which Ra is a group of formula (i) in which P1 is phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring or Ra is a group of formula (ii) wherein P?2 and P3¿ are independently phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring or a bicyclic heterocyclic group; L is a group of formula -Y-C(=V)-DG- in which Y is -NH-, NR5 where R5 is C¿1-6?alkyl, or Y is -CH2- or -O-; V is oxygen or sulphur; D is nitrogen, carbon or a CH group, G is hydrogen or C1-6alkyl, R?y¿ is a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or Ry is a group of formula -NReRf. The compounds have now been found to exhibit combined 5HT¿1A?, 5HT1B and 5HT1D receptor antagonist activity. It is expected that such compounds will be useful for the treatment and prophylaxis of various CNS disorders with the advantage of a relatively fast onset of action. |