Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3f8ff461e6c2a10143edd13725c130f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7a2410c113e426af8051bf4ca60c694 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_029a8fa5655777d3690ee2f6762c2a56 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-912 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-78 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6887 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
filingDate |
1998-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31506c1f9d611447b37b1aa17bdb8948 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2855623e5c9c601b90ae9005bd152046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bae2389f0a56c445b96167b68baf9997 |
publicationDate |
1998-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-9845711-A2 |
titleOfInvention |
Assay for ligands to tyrosine kinase receptors |
abstract |
The present invention provides for use of a molecule capable of competing with collagen for binding to the extracellular domain of a Tyro-10 (DDR-2) or NEP (DDR-1) receptor in the manufacture of a medicament for use in a therapeutic method which comprises modulating or blocking the binding of collagen to Tyro-10 (DDR-2) or NEP (DDR-1) extracellular domain-expressing cells. The invention also provides for a screen for a polypeptide ligand that can bind to the Tyro-10 (DDR-2) or NEP (DDR-1) receptor and that can promote a differential function and/or influence the phenotype, such as growth and/or proliferation, of cells that bear the receptor. The present invention also provides a method of screening for a molecule capable of competing with collagen for binding to the extracellular domain of a Tyro-10 (DDR-2) or NEP (DDR-1) receptor comprising contacting a sample suspected of containing the molecule with the extracellular domain of a Tyro-10 (DDR-2) or NEP (DDR-1) receptor in the presence of collagen under conditions in which the collagen is capable of binding to the extracellular domain and detecting binding of the molecule to the Tyro-10 (DDR-2) or NEP (DDR-1) receptor extracellular domain. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1026504-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6638725-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2518157-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012146585-A1 |
priorityDate |
1997-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |