| abstract |
The present invention pertains to combination nuclear medicine involving radiopharmaceuticals for diagnostic imaging and for therapy of tumors. More specifically the invention includes pharmaceutical compositions and methods of treatment, diagnosis, and radioimaging by genetic engineering designed to accumulate radioisotopes in cells. The combination of genetic engineering to confer radioisotope accumulation by cells with introduction of radioisotopes has many uses including radioimaging in vitro or in vivo to locate or identify gene expression, radiation therapy for killing neoplastic and non-neoplastic cells, and diagnostic applications. Genetic constructs, vectors, transformed cells and methods are disclosed. |