| abstract |
This invention relates to novel compounds of 3,4-dialkoxyphenyl derivatives having the activity to inhibit tumor necrosis factor-α(TNF-α). In more detail, this invention is directed to the preparation processes of the novel compounds of formula (1), and a pharmaceutically acceptable salt thereof, and pharmaceutical compositions possessing important biological therapeutic effect on inflammatory and autoimmune diseases associated with a detrimental excess of tumor necrosis factor-α. |